Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 14/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.67 |
| ▸ | JAK2 | O60674 | 6/20 | 0.57 |
| ▸ | JUN | P05412 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765330 | 0.90 | MAPK10 (0.80) | MAPK10MAPK8MAPK9JAK2JUN | |
| SCHEMBL3748403 | 0.89 | MAPK10 (0.71) | MAPK10MAPK8MAPK9JAK2JUN | |
| SCHEMBL3760337 | 0.81 | MAPK10 (0.74) | MAPK10MAPK8MAPK9JAK2 | |
| SCHEMBL3758473 | 0.80 | MAPK10 (1.00) | MAPK10MAPK8MAPK9JAK2JUN | |
| SCHEMBL3756221 | 0.80 | MAPK10 (0.82) | MAPK10MAPK8MAPK9JAK2JUN | |
| SCHEMBL3751062 | 0.80 | MAPK10 (0.61) | MAPK10MAPK8MAPK9JAK2 | |
| SCHEMBL8063344 | 0.79 | MAPK8 (0.63) | MAPK10MAPK8MAPK9JAK2 | |
| SCHEMBL3756330 | 0.79 | MAPK10 (0.63) | MAPK10MAPK8MAPK9JAK2 | |
| SCHEMBL3758673 | 0.79 | MAPK10 (0.84) | MAPK10MAPK8MAPK9JAK2 | |
| SCHEMBL3760321 | 0.78 | MAPK10 (0.62) | MAPK10MAPK8MAPK9JAK2JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |