Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.37 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4545994 | 0.89 | MAPT (0.43) | MKNK1TSHRCSF1RKDM4ENPC1 | |
| SCHEMBL1038046 | 0.85 | MAPT (0.42) | L3MBTL1NR4A2TSHRHTTEGFR | |
| SCHEMBL8059139 | 0.84 | MAP2K1 (0.43) | L3MBTL1NR4A2TSHRHTTCSF1R | |
| SCHEMBL30746852 | 0.82 | NR4A2 (0.40) | MKNK1CYP3A4P2RY6P2RY14L3MBTL1 | |
| SCHEMBL1038083 | 0.82 | NR4A2 (0.40) | MKNK1CYP3A4P2RY6P2RY14L3MBTL1 | |
| SCHEMBL1078430 | 0.79 | CYP2C9 (0.45) | CYP3A4NR4A2CSF1RKDM4ENPC1 | |
| SCHEMBL19119163 | 0.78 | NR4A2 (0.36) | CYP3A4P2RY6P2RY14L3MBTL1NR4A2 | |
| SCHEMBL3886544 | 0.77 | MEN1 (0.45) | KMT2ASMN1; SMN2 | |
| SCHEMBL1075382 | 0.74 | MAP2K1 (0.43) | CYP3A4EGFRKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL1077717 | 0.73 | NR4A2 (0.40) | MKNK1CYP3A4P2RY6P2RY14NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036020-A1 | MEK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |