Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805910 | 0.84 | SCN9A (1.00) | SCN9ANPC1RAB9A | |
| SCHEMBL787531 | 0.83 | SCN9A (1.00) | SCN9A | |
| SCHEMBL29421433 | 0.83 | SCN9A (1.00) | SCN9A | |
| SCHEMBL21236966 | 0.76 | SCN9A (0.53) | SCN9A | |
| SCHEMBL16174381 | 0.75 | SCN9A (0.66) | SCN9ATSHR | |
| SCHEMBL17076600 | 0.74 | SCN9A (0.57) | SCN9ANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL14920033 | 0.73 | SCN9A (0.83) | SCN9AKCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL787277 | 0.71 | SCN9A (1.00) | SCN9A | |
| SCHEMBL787278 | 0.71 | SCN9A (0.86) | SCN9A | |
| SCHEMBL21236944 | 0.70 | SCN9A (0.77) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616441-B1 | PYRIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA LP (US) | 2019-08-07 | — | — | EP | disclosed |
| WO-2012035421-A2 | PYRIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. (US) | 2012-03-22 | — | — | WO | disclosed |