Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.71 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | SERPINE1 | P05121 | 5/20 | 0.52 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059610 | 1.00 | DHODH (0.71) | DHODHTRPM8KDM4EHSD17B10RAB9A | |
| SCHEMBL8059517 | 0.93 | KDM4E (0.62) | DHODHTRPM8KDM4EHSD17B10RAB9A | |
| SCHEMBL8059511 | 0.93 | KDM4E (0.62) | DHODHTRPM8KDM4EHSD17B10RAB9A | |
| SCHEMBL8060340 | 0.92 | DHODH (0.60) | DHODHTRPM8KDM4EHSD17B10RAB9A | |
| SCHEMBL8060343 | 0.92 | DHODH (0.60) | DHODHTRPM8KDM4EHSD17B10RAB9A | |
| SCHEMBL8060346 | 0.90 | KDM4E (0.58) | DHODHTRPM8KDM4EHSD17B10RAB9A | |
| SCHEMBL8060345 | 0.90 | KDM4E (0.58) | DHODHTRPM8KDM4EHSD17B10RAB9A | |
| SCHEMBL8048968 | 0.90 | KDM4E (0.58) | DHODHTRPM8KDM4EHSD17B10RAB9A | |
| SCHEMBL8048963 | 0.90 | KDM4E (0.58) | DHODHTRPM8KDM4EHSD17B10RAB9A | |
| SCHEMBL8065905 | 0.90 | DHODH (0.71) | DHODHTRPM8KDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |