Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.54 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.54 |
| ▸ | CPB1 | P15086 | 1/20 | 0.53 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18085426 | 1.00 | HTT (0.60) | HTTLMNASMN1; SMN2TGM2SLC1A3 | |
| SCHEMBL19754817 | 0.92 | SLC1A3 (0.60) | HTTLMNASMN1; SMN2TGM2SLC1A3 | |
| SCHEMBL22043447 | 0.92 | SLC1A3 (0.60) | HTTLMNASMN1; SMN2TGM2SLC1A3 | |
| SCHEMBL18085394 | 0.92 | SLC1A3 (0.60) | HTTLMNASMN1; SMN2TGM2SLC1A3 | |
| SCHEMBL11993680 | 0.88 | HTT (0.53) | HTTLMNASMN1; SMN2TGM2SLC1A3 | |
| SCHEMBL24923326 | 0.88 | HTT (0.62) | HTTLMNASMN1; SMN2TGM2SLC1A3 | |
| SCHEMBL20382947 | 0.88 | HTT (0.62) | HTTLMNASMN1; SMN2TGM2SLC1A3 | |
| SCHEMBL15186352 | 0.87 | HTT (0.64) | HTTLMNASMN1; SMN2TGM2SLC1A3 | |
| SCHEMBL13480421 | 0.86 | HTT (0.63) | HTTLMNASMN1; SMN2TGM2SLC1A3 | |
| SCHEMBL10032568 | 0.86 | HTT (0.67) | HTTLMNASMN1; SMN2TGM2SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096763-A | ADMINISTERING TO THE PATIENTS A2-OXO-1-BENZIMIDAZOLINYL)PIPERIDIN-1-YL)ALKYL)-1,2BENZISOTHIA ZOL-3-(2H)-ONE DERIVATIVE AS ALPHA-1A ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 2000-08-01 | — | — | US | disclosed |
| US-5952351-A | DERIVATIVES OF 1,1,3-TRIOXO-2-((2-OXOBENZIMIDAZOLIN- OR BENZOXAZOLIN-2-YL)-PIPERIDIN-4,1-YLENE-)-1,2-BENZISOTHIAZOLE; TREATMENT OF BENIGN PROSTATIC HYPERPLASIA; SELECTIVE RELAXATION OF SMOOTH MUSCLE WITHOUT INDUCING HYPOTENSION | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0812196-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-05-20 | — | — | EP | disclosed |
| EP-0812196-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996025934-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | disclosed |