Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.58 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.55 |
| ▸ | STS | P08842 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4470679 | 1.00 | JAK2 (0.58) | JAK2JAK1GPR119STSMEN1 | |
| SCHEMBL8056082 | 1.00 | JAK2 (0.58) | JAK2JAK1GPR119STSMEN1 | |
| SCHEMBL8056077 | 1.00 | JAK2 (0.58) | JAK2JAK1GPR119STSMEN1 | |
| SCHEMBL3642479 | 0.95 | JAK2 (0.56) | JAK2JAK1GPR119STSMEN1 | |
| SCHEMBL16963755 | 0.95 | JAK2 (0.56) | JAK2JAK1GPR119STSMEN1 | |
| SCHEMBL3335624 | 0.90 | JAK2 (0.62) | JAK2JAK1GPR119STSTP53 | |
| SCHEMBL649847 | 0.88 | KCNK3 (0.55) | JAK2JAK1GPR119STS | |
| SCHEMBL584450 | 0.88 | KCNK3 (0.55) | JAK2JAK1GPR119STS | |
| SCHEMBL16053284 | 0.88 | KCNK3 (0.55) | JAK2JAK1GPR119STS | |
| SCHEMBL6636263 | 0.88 | JAK2 (0.52) | JAK2JAK1GPR119STSBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1061076-A1 | N-ACYL CYCLIC AMINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-12-20 | — | — | EP | disclosed |
| US-6140333-A | FOR TREATMENT AND/OR PROPHYLAXIS OF DISEASES INCLUDE SUCH RESPIRATORY DISEASES AS CHRONIC OBSTRUCTIVE PULMONARY DISEASES, CHRONIC BRONCHITIS, ASTHMA, CHRONIC RESPIRATORY OBSTRUCTION, PULMONARY FIBROSIS, PULMONARY EMPHYSEMA | BANYU PHARMACEUTICAL CO LTD (JP) | 2000-10-31 | — | — | US | disclosed |