Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KLK7 | P49862 | 1/20 | 0.52 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PRNP | P04156 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806036 | 0.88 | KDR (0.67) | KDRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL806125 | 0.88 | KDR (0.72) | KDRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL806103 | 0.88 | KDR (0.78) | KDRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL788175 | 0.87 | KDR (0.78) | KDRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL788057 | 0.87 | KDR (0.77) | KDRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL788243 | 0.86 | KDR (0.66) | KDRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL788156 | 0.86 | KDR (0.67) | KDRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL794208 | 0.85 | KDR (0.79) | KDRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL787948 | 0.85 | KDR (0.66) | KDRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL787703 | 0.85 | KDR (0.66) | KDRMEN1KMT2AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |