Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.75 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.75 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | PLD2 | O14939 | 14/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 12/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL795275 | 0.89 | PIK3CD (0.74) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL794940 | 0.89 | PIK3CD (0.78) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL795749 | 0.89 | PIK3CD (0.71) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL10229888 | 0.89 | PIK3CD (0.75) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL15485542 | 0.87 | PIK3CD (0.85) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL15485536 | 0.86 | PIK3CD (0.78) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL15485602 | 0.86 | PIK3CD (0.83) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL787981 | 0.86 | PIK3CD (1.00) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL15485700 | 0.86 | PIK3CD (0.83) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL787863 | 0.86 | PIK3CD (0.82) | PIK3CDPIK3R1PDE2APDE4APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037226-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |