Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.59 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.59 |
| ▸ | PLD2 | O14939 | 12/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 10/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18175774 | 0.88 | PIK3CD (0.72) | PIK3CDPIK3R1PLD2PLD1OPRM1 | |
| SCHEMBL787847 | 0.86 | PIK3CD (0.58) | PIK3CDPIK3R1PLD2PLD1OPRM1 | |
| SCHEMBL806209 | 0.85 | PIK3CD (0.70) | PIK3CDPIK3R1PLD2PLD1OPRM1 | |
| SCHEMBL789021 | 0.85 | PIK3CD (0.57) | PIK3CDPIK3R1PLD2PLD1OPRM1 | |
| SCHEMBL10227569 | 0.85 | PIK3CD (0.81) | PIK3CDPIK3R1PLD2PLD1KDM4E | |
| SCHEMBL787971 | 0.83 | PIK3CD (0.68) | PIK3CDPIK3R1PLD2PLD1OPRM1 | |
| SCHEMBL788976 | 0.81 | PIK3CD (0.64) | PIK3CDPIK3R1PLD2PLD1OPRM1 | |
| SCHEMBL15485696 | 0.78 | PIK3CD (0.77) | PIK3CDPIK3R1PLD2PLD1OPRM1 | |
| SCHEMBL10229565 | 0.77 | PIK3CD (0.79) | PIK3CDPIK3R1PLD2PLD1 | |
| SCHEMBL787863 | 0.77 | PIK3CD (0.82) | PIK3CDPIK3R1PLD2PLD1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037226-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |