Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.89 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL30666401 | 0.97 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL121114 | 0.97 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL672694 | 0.97 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL10768485 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL5676981 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL29152424 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL11056334 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL7651730 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL29152416 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL2891377 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664324-B2 | COATING MATERIAL COMPOSITION | YUHO CHEMICALS INC (JP) | 2000-06-28 | — | — | EP | disclosed |
| US-5912298-A | POLYURETHANES, CALCIUM COMPOUNDS FOR CROSSLINKING | YUHO CHEMICALS, INC. (JP) | 1999-06-15 | — | — | US | disclosed |
| US-5541265-A | FLOOR POLISHES PREPARED BY CROSSLINKING ACRYLIC EMULSION WITH CALCIUM COMPOUND | YUHO CHEMICALS, INC. (JP) | 1996-07-30 | — | — | US | disclosed |
| EP-0664324-A1 | COATING MATERIAL COMPOSITION | YUHO CHEMICALS INC. (JP) | 1995-07-26 | — | — | EP | disclosed |