SCHEMBL8064095

SCHEMBL8064095

COC(=O)C(=NOC(F)F)c1ccccc1CBr

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.46
ALDH1A1 P00352 4/20 0.37
LMNA P02545 1/20 0.37
KDM4E B2RXH2 4/20 0.33
HPGD P15428 4/20 0.33
HSD17B10 Q99714 3/20 0.33
RCE1 Q9Y256 1/20 0.33
PKM P14618 1/20 0.33
CFTR P13569 1/20 0.33
TSHR P16473 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8061817 0.87 HIF1A (0.46) HIF1AALDH1A1LMNAKDM4EHPGD
SCHEMBL3621281 0.85 HIF1A (0.60) HIF1AALDH1A1LMNAKDM4EHPGD
SCHEMBL29391748 0.85 HIF1A (0.60) HIF1AALDH1A1LMNAKDM4EHPGD
SCHEMBL3621278 0.85 HIF1A (0.60) HIF1AALDH1A1LMNAKDM4EHPGD
SCHEMBL6703043 0.85 HIF1A (0.60) HIF1AALDH1A1LMNAKDM4EHPGD
SCHEMBL30007831 0.85 HIF1A (0.60) HIF1AALDH1A1LMNAKDM4EHPGD
SCHEMBL7215595 0.83 HIF1A (0.46) HIF1AALDH1A1LMNAKDM4EHPGD
SCHEMBL8766703 0.83 HIF1A (0.46) HIF1AALDH1A1LMNAKDM4EHPGD
SCHEMBL7215593 0.83 HIF1A (0.46) HIF1AALDH1A1LMNAKDM4EHPGD
SCHEMBL30007722 0.81 HIF1A (0.47) HIF1AALDH1A1LMNAKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0777645-B1 OXIME ETHERS AND THEIR USE AS PESTICIDES NOVARTIS AG (CH) 2000-06-14 EP disclosed
US-5935908-A PLANT GROWTH REGULATOR NOVARTIS CROP PROTECTION, INC. (US) 1999-08-10 US disclosed
EP-0844993-A2 PESTICIDAL INDAZOLE DERIVATIVES Novartis AG (CH) 1998-06-03 EP disclosed
US-5710314-A FUNGICIDES OR INSECTICIDES OF AROMATIC ETHERS WITH ESTER GROUPS OR AMIDES NOVARTIS CORPORATION (US) 1998-01-20 US disclosed
EP-0784606-A1 MICROBICIDES Novartis AG (CH) 1997-07-23 EP disclosed
EP-0777645-A1 OXIME ETHERS AND THEIR USE AS PESTICIDES Novartis AG (CH) 1997-06-11 EP disclosed
WO-1997007103-A2 PESTICIDAL INDAZOLE DERIVATIVES NOVARTIS AG (CH) 1997-02-27 WO disclosed
US-5583249-A INSECTICIDES, MITICIDES, MICROBIOCIDES FOR PLANTS CIBA-GEIGY CORPORATION (US) 1996-12-10 US disclosed
WO-1996010556-A1 MICROBICIDES NOVARTIS AG (CH) 1996-04-11 WO disclosed
WO-1996006072-A1 OXIME ETHERS AND THEIR USE AS PESTICIDES CIBA-GEIGY AG (CH) 1996-02-29 WO disclosed