Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 18/20 | 0.66 |
| ▸ | CTRC | Q99895 | 1/20 | 0.64 |
| ▸ | CTSG | P08311 | 1/20 | 0.61 |
| ▸ | ELANE | P08246 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049020 | 0.91 | CMA1 (0.75) | CMA1CTRCCTSGELANE | |
| SCHEMBL8060576 | 0.90 | CMA1 (0.78) | CMA1CTRCCTSG | |
| SCHEMBL8061333 | 0.90 | CMA1 (0.74) | CMA1CTRCCTSG | |
| SCHEMBL8444748 | 0.89 | CMA1 (0.78) | CMA1CTRCCTSGELANE | |
| SCHEMBL7156029 | 0.88 | CMA1 (0.78) | CMA1CTSG | |
| SCHEMBL8061814 | 0.88 | ELANE (0.58) | CMA1CTRCCTSGELANE | |
| SCHEMBL8066009 | 0.87 | CMA1 (0.68) | CMA1CTRCCTSG | |
| SCHEMBL8061868 | 0.87 | CMA1 (0.78) | CMA1CTRCCTSG | |
| SCHEMBL8061805 | 0.86 | CMA1 (0.62) | CMA1CTRCCTSGELANE | |
| SCHEMBL8066027 | 0.85 | CMA1 (0.78) | CMA1CTRCCTSGELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080738-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE USED FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II | YOSHITOMI PHARMACEUTICALS INDUSTRIES, LTD. (JP) | 2000-06-27 | — | — | US | disclosed |
| EP-0940400-A1 | NOVEL HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USES THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-08 | — | — | EP | disclosed |