Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.56 |
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.43 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | STS | P08842 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013761 | 0.86 | NR1H2 (0.55) | NR1H2EEDRBBP4SUZ12EZH2 | |
| SCHEMBL4041973 | 0.86 | NR1H2 (0.45) | NR1H2ESR2LMNAALDH1A1MEN1 | |
| SCHEMBL1938024 | 0.85 | NR1H2 (0.57) | NR1H2EEDRBBP4SUZ12EZH2 | |
| SCHEMBL1939135 | 0.85 | NR1H2 (0.54) | NR1H2EEDRBBP4SUZ12EZH2 | |
| SCHEMBL17790092 | 0.84 | NR1H2 (0.53) | NR1H2EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21810238 | 0.83 | NR1H2 (0.55) | NR1H2EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21809908 | 0.82 | NR1H2 (0.51) | NR1H2EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21809843 | 0.81 | NR1H2 (0.52) | NR1H2EEDRBBP4SUZ12EZH2 | |
| SCHEMBL4041240 | 0.78 | NR1H2 (0.44) | NR1H2ESR2LMNAALDH1A1MAPT | |
| SCHEMBL17838158 | 0.76 | NR1H2 (0.47) | NR1H2ESR2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044007-A2 | 1,2,3,4-TETRAHYDROPYRROLO[1,2-A]PYRAZINE-6-CARBOXAMIDE AND 2,3,4,5-TETRAHYDROPYRROLO[1,2-A][1,4]-DIAZÉPINE-7-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-09 | — | — | WO | disclosed |