Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070006 | 1.00 | PDE4B (0.41) | PDE4BPDE4APDE4DPDE4CMAPT | |
| SCHEMBL15906094 | 0.87 | PDE4B (0.43) | PDE4BPDE4APDE4DPDE4CSMN1; SMN2 | |
| SCHEMBL15906169 | 0.87 | PDE4B (0.43) | PDE4BPDE4APDE4DPDE4CSMN1; SMN2 | |
| SCHEMBL8070008 | 0.85 | PDE4D (0.42) | PDE4BPDE4APDE4DPDE4CMAPT | |
| SCHEMBL7918270 | 0.83 | PDE4B (0.44) | PDE4BPDE4DSMN1; SMN2 | |
| SCHEMBL8064986 | 0.83 | PDE4B (0.44) | PDE4BPDE4D | |
| SCHEMBL4324592 | 0.83 | AKR1C3 (0.46) | PDE4BPDE4APDE4DPDE4CMAPT | |
| SCHEMBL4324462 | 0.83 | AKR1C3 (0.46) | PDE4BPDE4APDE4DPDE4CMAPT | |
| SCHEMBL4324467 | 0.83 | AKR1C3 (0.46) | PDE4BPDE4APDE4DPDE4CMAPT | |
| SCHEMBL8068535 | 0.81 | HDAC7 (0.49) | PDE4BPDE4DGRM2HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |