Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | UGCG | Q16739 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7801341 | 0.92 | MEN1 (0.43) | MEN1KMT2AKCNK3KCNK9RXFP1 | |
| SCHEMBL8182722 | 0.92 | KDR (0.43) | MEN1KMT2AKITKDRKLKB1 | |
| SCHEMBL7799939 | 0.91 | MEN1 (0.43) | MEN1KMT2AKCNK3KCNK9RXFP1 | |
| SCHEMBL7791943 | 0.90 | MEN1 (0.42) | MEN1KMT2AKCNK3KCNK9RXFP1 | |
| SCHEMBL7792082 | 0.89 | MEN1 (0.42) | MEN1KMT2AKCNK3KCNK9RXFP1 | |
| SCHEMBL7799951 | 0.88 | MEN1 (0.49) | MEN1KMT2AMAPTNR1I2UGCG | |
| SCHEMBL7799980 | 0.86 | HSD17B10 (0.43) | MEN1KMT2ARXFP1MAPTNR1I2 | |
| SCHEMBL7797946 | 0.86 | KMT2A (0.43) | MEN1KMT2AMAPTNR1I2UGCG | |
| SCHEMBL7801319 | 0.86 | KMT2A (0.43) | MEN1KMT2ARXFP1MAPTNR1I2 | |
| SCHEMBL7801338 | 0.86 | KMT2A (0.45) | MEN1KMT2AMAPTNR1I2UGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025087-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999021836-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-05-06 | — | — | WO | disclosed |