Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.58 |
| ▸ | KDM1A | O60341 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | F3 | P13726 | 1/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8082841 | 0.93 | HDAC1 (0.52) | HDAC1HDAC3HDAC2KCNH2HDAC8 | |
| SCHEMBL3640161 | 0.90 | HDAC1 (0.64) | HDAC1HDAC3HDAC2KCNH2HDAC8 | |
| SCHEMBL8075188 | 0.89 | HDAC1 (0.61) | HDAC1HDAC3HDAC2KCNH2HDAC8 | |
| SCHEMBL16168325 | 0.89 | HDAC1 (0.56) | HDAC1HDAC3HDAC2KCNH2HDAC8 | |
| SCHEMBL3642860 | 0.87 | HDAC1 (0.57) | HDAC1HDAC3HDAC2KCNH2HDAC8 | |
| SCHEMBL1435252 | 0.86 | HDAC1 (0.74) | HDAC1HDAC3HDAC2KCNH2HDAC8 | |
| SCHEMBL8113197 | 0.86 | HDAC1 (0.75) | HDAC1HDAC3HDAC2KCNH2HDAC8 | |
| SCHEMBL3771406 | 0.85 | HDAC1 (0.56) | HDAC1HDAC3HDAC2KCNH2HDAC8 | |
| SCHEMBL3648233 | 0.85 | HDAC1 (0.54) | HDAC1HDAC3HDAC2HDAC6NAMPT | |
| SCHEMBL3649530 | 0.85 | HDAC1 (0.53) | HDAC1HDAC3HDAC2KCNH2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461189-B2 | Pyridyl derivatives as histone deacetylase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-8461189-B2 | Pyridyl derivatives as histone deacetylase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20100324092-A1 | PYRIDYL AND PYRIMIDINYL DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
| US-20100324092-A1 | PYRIDYL AND PYRIMIDINYL DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
| WO-2009005638-A2 | PYRIDYL AND PYRIMIDINYL DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324092-A1 | PYRIDYL AND PYRIMIDINYL DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | BRDT, HDAC5, HDAC1 | HDAC1 3/4885HDAC3 5/4885HDAC2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.