Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | NQO2 | P16083 | 1/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.58 |
| ▸ | FECH | P22830 | 1/20 | 0.58 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.58 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | PRKDC | P78527 | 1/20 | 0.58 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.58 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.58 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.58 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.58 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.58 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.58 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.58 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11980645 | 0.90 | RAF1 (0.57) | RETRIPK2NQO2CSNK2A2FECH | |
| SCHEMBL8071440 | 0.90 | RAF1 (0.58) | RETRIPK2NQO2CSNK2A2FECH | |
| SCHEMBL6943751 | 0.88 | RAF1 (0.73) | RETRIPK2NQO2CSNK2A2FECH | |
| SCHEMBL8076322 | 0.88 | MTOR (0.64) | RETRIPK2NQO2CSNK2A2FECH | |
| SCHEMBL6940368 | 0.87 | MTOR (0.65) | RETRIPK2NQO2CSNK2A2FECH | |
| SCHEMBL14536810 | 0.87 | MTOR (0.65) | RETRIPK2NQO2CSNK2A2FECH | |
| SCHEMBL6942945 | 0.87 | MTOR (0.65) | RETRIPK2NQO2CSNK2A2FECH | |
| SCHEMBL12593574 | 0.85 | RAF1 (0.54) | RETRIPK2NQO2CSNK2A2FECH | |
| SCHEMBL594970 | 0.85 | RAF1 (0.79) | RETPIK3CAMTORPIK3CGPRKDC | |
| SCHEMBL593552 | 0.84 | TNK2 (0.59) | RETRIPK2NQO2CSNK2A2FECH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163468-A1 | Fused Bicyclic mTor Inhibitors | OSI PHARMACEUTICALS, INC. | 2009-06-25 | — | — | US | disclosed |
| US-20090163468-A1 | Fused Bicyclic mTor Inhibitors | OSI PHARMACEUTICALS, INC. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163468-A1 | Fused Bicyclic mTor Inhibitors | MTOR, RICTOR, MAPKAP1 | RET 744/4885RIPK2 1316/4885NQO2 2722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.