SCHEMBL806957

SCHEMBL806957

COc1ccc2c(c1)[C@@]1(C)CCCC(C)(C)C1CC2

nearest known ligand 0.76

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
POLA1 P09884 6/20 0.76
CYP3A4 P08684 2/20 0.71
CYP2C9 P11712 1/20 0.71
TSHR P16473 1/20 0.71
CYP2C19 P33261 1/20 0.71
ALDH1A1 P00352 1/20 0.54
THRB P10828 1/20 0.54
MAPK1 P28482 1/20 0.54
NR1H2 P55055 6/20 0.53
NR1H3 Q13133 6/20 0.53
CYP19A1 P11511 1/20 0.44
HSP90AA1 P07900 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15978322 1.00 POLA1 (0.76) POLA1CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL14047593 0.86 POLA1 (0.73) POLA1CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL13165178 0.83 CYP3A4 (1.00) POLA1CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL19770999 0.83 CYP3A4 (1.00) POLA1CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL5530208 0.83 CYP3A4 (1.00) POLA1CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL280198 0.82 POLA1 (1.00) POLA1CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL5510769 0.82 POLA1 (1.00) POLA1CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL12872352 0.82 POLA1 (1.00) POLA1CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL24177920 0.81 POLA1 (0.81) POLA1CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL19770990 0.81 POLA1 (0.81) POLA1CYP3A4CYP2C9TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012037069-A2 UNIQUE HALOGEN-INDUCED CYCLIZATIONS, REAGENTS THEREFOR, AND COMPOUNDS PRODUCED THEREBY THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-03-22 WO disclosed