Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.71 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30213808 | 0.90 | LCK (0.58) | PTPN1LCKPTPN11KDM4EALDH1A1 | |
| SCHEMBL69179 | 0.90 | LCK (0.58) | PTPN1LCKPTPN11KDM4EALDH1A1 | |
| SCHEMBL28311980 | 0.88 | PLA2G2D (0.60) | PTPN1PTPN11KDM4EALDH1A1HPGD | |
| SCHEMBL23909525 | 0.86 | PTPN1 (0.51) | PTPN1LCKPTPN11KDM4EALDH1A1 | |
| SCHEMBL30362287 | 0.86 | PTPN1 (0.51) | PTPN1LCKPTPN11KDM4EALDH1A1 | |
| SCHEMBL23909566 | 0.86 | PTPN1 (0.51) | PTPN1LCKKDM4EALDH1A1HPGD | |
| SCHEMBL70015 | 0.83 | PTPN1 (1.00) | PTPN1PTPN11KDM4EALDH1A1HPGD | |
| SCHEMBL29404396 | 0.83 | PTPN1 (1.00) | PTPN1PTPN11KDM4EALDH1A1HPGD | |
| SCHEMBL2484301 | 0.83 | KDM4E (0.55) | PTPN1KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL30293952 | 0.82 | PTPN1 (0.77) | PTPN1PTPN11KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030853-A1 | NOVEL SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM | ARIAD PHARMACEUTICALS, INC. (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024442-A1 | NOVEL SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM | ARIAD PHARMACEUTICALS, INC. (US) | 1999-05-20 | — | — | WO | disclosed |