Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14555727 | 0.88 | IGF1R (0.40) | IGF1RALOX15HDAC1HDAC8KDM1A | |
| SCHEMBL29331986 | 0.88 | IGF1R (0.40) | IGF1RALOX15HDAC1HDAC8KDM1A | |
| SCHEMBL8084327 | 0.86 | KDM1A (0.35) | KDM1AKCNH2KDM1BPARP1 | |
| SCHEMBL6649880 | 0.82 | DAO (0.41) | IGF1RALOX15HDAC1HDAC8 | |
| SCHEMBL5866466 | 0.81 | HTR2A (0.48) | SKP2 | |
| SCHEMBL17295168 | 0.81 | KDM1A (0.34) | IGF1RALOX15HDAC1HDAC8KDM1A | |
| SCHEMBL10412776 | 0.81 | IGF1R (0.38) | IGF1RALOX15HDAC1HDAC8SKP2 | |
| SCHEMBL9579438 | 0.81 | DAO (0.40) | IGF1RALOX15HDAC1HDAC8 | |
| SCHEMBL7788951 | 0.80 | HTR2A (0.52) | — | |
| SCHEMBL13564077 | 0.80 | HTR2A (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655456-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2000-09-06 | — | — | EP | disclosed |
| US-5624918-A | Phosphonic diester derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1997-04-29 | — | — | US | disclosed |
| EP-0655456-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-05-31 | — | — | EP | disclosed |