Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | ZDHHC20 | Q5W0Z9 | 2/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1205488 | 0.98 | SPHK2 (0.39) | SPHK2SPHK1ZDHHC20ZDHHC2NOS3 | |
| SCHEMBL1937313 | 0.96 | SPHK2 (0.42) | SPHK2SPHK1ZDHHC20ZDHHC2NOS3 | |
| SCHEMBL1937656 | 0.96 | SPHK2 (0.42) | SPHK2SPHK1ZDHHC20ZDHHC2NOS3 | |
| SCHEMBL4465867 | 0.96 | SPHK2 (0.42) | SPHK2SPHK1ZDHHC20ZDHHC2NOS3 | |
| SCHEMBL1938682 | 0.96 | SPHK2 (0.42) | SPHK2SPHK1ZDHHC20ZDHHC2NOS3 | |
| SCHEMBL1937984 | 0.96 | SPHK2 (0.42) | SPHK2SPHK1ZDHHC20ZDHHC2NOS3 | |
| SCHEMBL20361795 | 0.92 | GRIN2D (0.37) | SPHK2SPHK1NOS3NOS1NOS2 | |
| SCHEMBL9235649 | 0.86 | — | — | |
| SCHEMBL1505132 | 0.86 | — | — | |
| SCHEMBL19371464 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792291-B1 | PROTEIN AFFECTING KATP CHANNELS | UPJOHN CO (US) | 2000-09-20 | — | — | EP | disclosed |
| US-5925742-A | GLYCOPROTEIN OF 54,000 TO 60,000 DALTONS FROM RAT CELLS AND CAPABLE OF BINDING N-(3-AZIDO-5-IODOPHENYL)-N'-CYANO-N''-(1,1-DIMETHYLPROPYL)-GUANIDINE; MODULATORS OF ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNELS | PHARMACIA & UPJOHN COMPANY (US) | 1999-07-20 | — | — | US | disclosed |
| US-5856449-A | GLYCOPROTEIN | PHARMACIA & UPJOHN COMPANY (US) | 1999-01-05 | — | — | US | disclosed |
| US-5525742-A | IDENTIFICATION OF BIOCHEMICAL COMPONENTS FORMING ATP-SENSITIVE POTASSIUM CHANNELS IN SMOOTH MUSCLE CELLS | THE UPJOHN COMPANY (US) | 1996-06-11 | — | — | US | disclosed |