SCHEMBL8071398

SCHEMBL8071398

CC(C)(C)OC(=O)C(N)(C=O)Cc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.45
HIF1A Q16665 1/20 0.45
SLC6A2 P23975 1/20 0.44
TAAR1 Q96RJ0 1/20 0.44
MMP8 P22894 1/20 0.40
CYP3A4 P08684 2/20 0.40
ALDH1A1 P00352 2/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA7 P43166 1/20 0.40
CA14 Q9ULX7 1/20 0.40
ATM Q13315 1/20 0.39
CTSK P43235 1/20 0.39
TSHR P16473 1/20 0.39
RECQL P46063 2/20 0.38
CYP1A2 P05177 1/20 0.38
AKT1 P31749 2/20 0.38
PPARG P37231 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5711180 1.00 SMN1; SMN2 (0.45) SMN1; SMN2HIF1ASLC6A2TAAR1MMP8
SCHEMBL28603553 0.85 SMN1; SMN2 (0.39) SMN1; SMN2CYP3A4ALDH1A1CYP2C9CYP2C19
SCHEMBL27535125 0.85 CA12 (0.41) SMN1; SMN2HIF1AALDH1A1CA12CA1
SCHEMBL27535172 0.85 CYP3A4 (0.48) SMN1; SMN2SLC6A2CYP3A4CYP2C9CYP2C19
SCHEMBL3286267 0.84 PPARG (0.38) TAAR1ALDH1A1PPARGPPARA
SCHEMBL3287116 0.83 KDM4E (0.47) SMN1; SMN2ALDH1A1CYP2C9CYP2C19TSHR
SCHEMBL8287363 0.81 SMN1; SMN2 (0.50) SMN1; SMN2HIF1ASLC6A2TAAR1MMP8
SCHEMBL7345507 0.80 PTPN1 (0.49) SMN1; SMN2HIF1ASLC6A2ALDH1A1CYP2C9
SCHEMBL27513616 0.80 PTPN1 (0.49) SMN1; SMN2HIF1ASLC6A2ALDH1A1CYP2C9
SCHEMBL8385923 0.79 SMN1; SMN2 (0.60) SMN1; SMN2HIF1ASLC6A2TAAR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE36718-E 3-AMINO-1-NITRO-4-PHENYL-2-BUTANOL DERIVATIVES KANEKA CORPORATION (JP) 2000-05-30 US claimed
US-5616726-A AN 3-AMINO-1-NITRO-4-PHENYL-2-BUTANOL BY ADDING NITROMETHANE STEREOSELECTIVELY IN THE PRESENCE OF A BASE TO AN OPTICAL ACTIVE AMINOALDEHYDE; CHEMICAL INTERMEDIATES FOR DRUGS; E.G. THE ANTICARCINOGENIC AGENT, BESTATIN KANEKA CORPORATION (JP) 1997-04-01 US claimed
EP-0657415-A1 OPTICALLY ACTIVE AMINO ALCOHOL DERIVATIVE AND PROCESS FOR PRODUCING THE SAME KANEKA CORPORATION (JP) 1995-06-14 EP claimed
CN-1253442-C Novel thiazine and pyrazine derivatives SANTEN PHARMACEUTICAL CO LTD (JP) 2006-04-26 CN disclosed
CN-1372553-A Novel thiazine or pyrazine derivatives SANTEN PHARMACEUTICAL CO LTD (JP) 2002-10-02 CN disclosed