Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28178640 | 0.74 | SMN1; SMN2 (0.63) | MKNK1MKNK2HPGDNPC1RIPK1 | |
| SCHEMBL8150805 | 0.74 | HPGD (0.76) | HPGDMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2227506 | 0.74 | KCNH2 (0.77) | KCNH2MKNK1 | |
| SCHEMBL807327 | 0.74 | HPGD (0.53) | HPGDNPC1RAB9AGRM2ALDH1A1 | |
| SCHEMBL13968161 | 0.73 | KCNH2 (0.76) | KCNH2JAK2 | |
| SCHEMBL2749415 | 0.73 | KCNH2 (0.59) | KCNH2MKNK1MKNK2HPGDNPC1 | |
| SCHEMBL13952297 | 0.72 | HPGD (0.60) | HPGDRIPK1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL6102102 | 0.72 | HPGD (0.57) | KCNH2MKNK1MKNK2JAK2HPGD | |
| SCHEMBL10720943 | 0.71 | PHGDH (0.81) | HPGDKMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL31428791 | 0.71 | TSHR (0.68) | HPGDNPC1RAB9AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |