Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10801839 | 0.87 | MAPK1 (0.76) | MAPK1BRD4CREBBPP2RX7NPC1 | |
| SCHEMBL10210906 | 0.84 | MAPK1 (0.58) | MAPK1BRD4CREBBP | |
| SCHEMBL807217 | 0.83 | MAPK1 (0.60) | MAPK1BRD4CREBBPNPC1DPP4 | |
| SCHEMBL10211781 | 0.81 | MAPK1 (0.55) | MAPK1BRD4CREBBPP2RX7NPC1 | |
| SCHEMBL10211062 | 0.79 | PIP5K1C (0.57) | MAPK1 | |
| SCHEMBL807229 | 0.79 | BRD4 (0.59) | MAPK1BRD4CREBBPP2RX7 | |
| SCHEMBL10210824 | 0.79 | MAPK1 (0.49) | MAPK1BRD4CREBBPNPC1DPP4 | |
| SCHEMBL807192 | 0.78 | BRD4 (0.58) | MAPK1BRD4CREBBPP2RX7 | |
| SCHEMBL807225 | 0.78 | BRD4 (0.61) | MAPK1BRD4CREBBPP2RX7 | |
| SCHEMBL807232 | 0.78 | BRD4 (0.67) | MAPK1BRD4CREBBPP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615916-B1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-01-04 | — | — | EP | disclosed |
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |