Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Epinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 6/20 | 0.67 |
| ▸ | ADRB3 known ✓ | P13945 | 5/20 | 0.67 |
| ▸ | ADRB1 known ✓ | P08588 | 4/20 | 0.67 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.67 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.67 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.67 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.67 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.67 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.67 |
| ▸ | MAPT | P10636 | 8/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylephrine SCHEMBL15918950 | 0.84 | HIF1A (0.70) | TDP1KDM4EMAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL21248121 | 0.83 | TDP1 (0.84) | TDP1KDM4EMAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL28584300 | 0.83 | TDP1 (0.84) | TDP1KDM4EMAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL21248119 | 0.83 | TDP1 (0.84) | TDP1KDM4EMAPTADRB2HSD17B10 | |
| SCHEMBL6318456 | 0.83 | TDP1 (0.58) | TDP1KDM4EMAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL20493843 | 0.82 | KDM4E (1.00) | TDP1KDM4EMAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL11631789 | 0.82 | KDM4E (1.00) | TDP1KDM4EMAPTADRB2HSD17B10 | |
| Racepinephrine SCHEMBL3815 | 0.82 | KDM4E (1.00) | TDP1KDM4EMAPTADRB2HSD17B10 | |
| L-Adrenaline SCHEMBL11647 | 0.82 | KDM4E (1.00) | TDP1KDM4EMAPTADRB2HSD17B10 | |
| Epinephrine SCHEMBL2837188 | 0.82 | KDM4E (1.00) | TDP1KDM4EMAPTADRB2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090799-A | ADMINISTERING OXANDROLONE | BTG PHARMACEUTICALS CORP. (US) | 2000-07-18 | — | — | US | disclosed |