Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.81 |
| ▸ | PDE4A | P27815 | 2/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4191703 | 0.90 | PDE10A (1.00) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL4198452 | 0.83 | PDE10A (1.00) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL13909630 | 0.82 | PDE10A (0.80) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL4185917 | 0.81 | PDE10A (1.00) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL4196881 | 0.80 | PDE10A (0.77) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL13909638 | 0.80 | PDE10A (0.76) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL13909627 | 0.78 | PDE10A (0.74) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL4197475 | 0.78 | PDE10A (1.00) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL13909604 | 0.78 | PDE10A (0.73) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL4190061 | 0.77 | PDE10A (0.72) | PDE10APDE4APDE4BPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009025823-A1 | PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2009-02-26 | — | — | WO | disclosed |