SCHEMBL8074441

SCHEMBL8074441

CCNc1ccc(Oc2cccc(C(=O)O)n2)cc1C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.49
P2RX3 P56373 13/20 0.45
BRAF P15056 1/20 0.40
KDR P35968 1/20 0.40
MAPK14 Q16539 1/20 0.40
TNNI3K Q59H18 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.39
SCN9A Q15858 1/20 0.39
POLB P06746 1/20 0.38
ATM Q13315 1/20 0.38
BLM P54132 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
KDM4C Q9H3R0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8069624 0.89 MAPT (0.47) MAPTP2RX3BRAFKDRMAPK14
SCHEMBL7113286 0.88 MAPT (0.52) MAPTP2RX3BRAFKDRMAPK14
SCHEMBL7108276 0.82 MAPT (0.52) MAPTP2RX3KDRMRGPRX4SCN9A
SCHEMBL7111276 0.80 MAPT (0.53) MAPTP2RX3BRAFMRGPRX4SCN9A
SCHEMBL7108378 0.79 MAPT (0.49) MAPTP2RX3KDRMRGPRX4SCN9A
SCHEMBL7107327 0.79 MAPT (0.49) MAPTP2RX3BRAFKDRMAPK14
SCHEMBL7110923 0.79 MAPT (0.49) MAPTP2RX3MRGPRX4SCN9A
SCHEMBL7105794 0.78 MRGPRX4 (0.53) MAPTP2RX3MRGPRX4SCN9A
SCHEMBL7108325 0.76 MAPT (0.44) MAPTP2RX3MRGPRX4
SCHEMBL8070236 0.76 MAPT (0.42) MAPTP2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6159901-A 6-phenoxy picolinic acid alkylidene hydrazide derivative, process for producing the same and herbicide using the same KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-12-12 US disclosed
EP-1020444-A1 6-PHENOXYPICOLINIC ACID, ALKYLIDENEHYDRAZIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-07-19 EP disclosed