Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.53 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.50 |
| ▸ | GSR | P00390 | 2/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.48 |
| ▸ | GRM6 | O15303 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.48 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL6419228 | 1.00 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2GRIK1GRIK2 | |
| Aspartic Acid SCHEMBL7717425 | 1.00 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2GRIK1GRIK2 | |
| Aspartic Acid SCHEMBL307009 | 1.00 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2GRIK1GRIK2 | |
| Aspartic Acid SCHEMBL8023215 | 1.00 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2GRIK1GRIK2 | |
| Aspartic Acid SCHEMBL307008 | 1.00 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2GRIK1GRIK2 | |
| Aspartic Acid SCHEMBL28092959 | 1.00 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2GRIK1GRIK2 | |
| Aspartic Acid SCHEMBL3655651 | 0.97 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2GRIK1GRIK2 | |
| Aspartic Acid SCHEMBL425953 | 0.97 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2GRIK1GRIK2 | |
| Aspartic Acid SCHEMBL1526976 | 0.92 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GSR | |
| D-Aspartate SCHEMBL145539 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1024195-A1 | Coat protein genes of potyvirus of capsicum spp. and plants transformed therewith | Bejo Zaden B.V. (NL) | 2000-08-02 | — | — | EP | disclosed |
| CN-1238013-A | Method for detection of metastatic prostate cancer | MAYO FOUNDATION (US) | 1999-12-08 | — | — | CN | disclosed |