Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 6/20 | 0.38 |
| ▸ | TTR | P02766 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8075204 | 0.79 | KDM4E (0.47) | MRGPRX4CYP2C9RAB9ATAS2R14 | |
| SCHEMBL8077157 | 0.76 | MAPT (0.48) | TTRPOLB | |
| SCHEMBL9188388 | 0.70 | KDM4E (0.46) | MRGPRX4RAB9ATAS2R14 | |
| SCHEMBL5030934 | 0.69 | NPSR1 (0.52) | RXRANPC1POLBCYP2C9RAB9A | |
| SCHEMBL9139074 | 0.69 | HTT (0.57) | MRGPRX4RXRARXRBRXRGIDO1 | |
| SCHEMBL8439161 | 0.69 | IDO1 (0.42) | MRGPRX4RXRARXRBRXRGIDO1 | |
| SCHEMBL14892441 | 0.69 | MAPK8 (0.42) | MRGPRX4TAS2R14KCNK3KCNK9 | |
| SCHEMBL8439615 | 0.67 | IDO1 (0.41) | MRGPRX4RXRARXRBRXRGIDO1 | |
| SCHEMBL8081713 | 0.66 | HMGB1 (0.54) | RXRARXRBNPC1POLBCYP2C9 | |
| SCHEMBL15458031 | 0.66 | NPC1 (0.44) | RXRBNPC1POLBCYP2C9RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799198-B1 | ANTI-INFLAMMATORY COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5545669-A | Anti-inflammatory compounds | SMITHKLINE BEECHAM CORPORATION | 1996-08-13 | — | — | US | disclosed |
| WO-1995033460-A1 | ANTI-INFLAMMATORY COUMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-14 | — | — | WO | disclosed |
| US-5447957-A | Anti-inflammatory compounds | SMITHKLINE BEECHAM CORP. (US) | 1995-09-05 | — | — | US | disclosed |