Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15065016 | 0.80 | MAPK1 (0.59) | BRD4CREBBPMAPK1P2RX7 | |
| SCHEMBL15082111 | 0.80 | MAPK1 (0.59) | BRD4CREBBPMAPK1P2RX7 | |
| SCHEMBL807226 | 0.80 | MAPK1 (0.59) | BRD4CREBBPMAPK1P2RX7 | |
| SCHEMBL15065457 | 0.78 | CREBBP (0.55) | BRD4CREBBPMAPK1 | |
| SCHEMBL807246 | 0.77 | MAPK1 (0.61) | BRD4CREBBPMAPK1P2RX7 | |
| SCHEMBL807232 | 0.77 | BRD4 (0.67) | BRD4CREBBPMAPK1P2RX7 | |
| SCHEMBL807192 | 0.77 | BRD4 (0.58) | BRD4CREBBPMAPK1P2RX7 | |
| SCHEMBL17868173 | 0.76 | BRD4 (0.77) | BRD4CREBBPMAPK1P2RX7 | |
| SCHEMBL807225 | 0.74 | BRD4 (0.61) | BRD4CREBBPMAPK1P2RX7 | |
| SCHEMBL807436 | 0.73 | BRD4 (0.60) | BRD4CREBBPMAPK1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |