Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.58 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.43 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807217 | 0.87 | MAPK1 (0.60) | MAPK1MAPK3MAP2K1BRD4CREBBP | |
| SCHEMBL10210906 | 0.85 | MAPK1 (0.58) | MAPK1BRD4CREBBP | |
| SCHEMBL17868294 | 0.82 | BRD4 (0.71) | MAPK1BRD4CREBBPNPC1PIP5K1C | |
| SCHEMBL15065125 | 0.80 | — | — | |
| SCHEMBL807440 | 0.79 | PIP5K1C (0.53) | MAPK1PIP5K1C | |
| SCHEMBL15065270 | 0.78 | — | — | |
| SCHEMBL15064908 | 0.78 | — | — | |
| SCHEMBL10210896 | 0.77 | — | — | |
| SCHEMBL10211883 | 0.76 | MAPK1 (0.49) | MAPK1 | |
| SCHEMBL14791447 | 0.76 | MAPK1 (0.64) | MAPK1MAPK3MAP2K1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |