Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31412760 | 0.91 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL30533112 | 0.89 | NAALAD2 (0.61) | FOLH1ACEOPRM1 | |
| SCHEMBL2520304 | 0.88 | NAALAD2 (0.56) | BACE1BACE2ACE | |
| SCHEMBL2520307 | 0.88 | NAALAD2 (0.56) | BACE1BACE2ACE | |
| SCHEMBL30587433 | 0.87 | BACE1 (0.56) | BACE1BACE2PTPN1 | |
| SCHEMBL30587431 | 0.87 | BACE1 (0.56) | BACE1BACE2PTPN1 | |
| SCHEMBL30396564 | 0.87 | ACE (0.63) | FOLH1ACEOPRM1OPRD1 | |
| SCHEMBL25627066 | 0.87 | MME (0.57) | ACEOPRM1 | |
| SCHEMBL30587432 | 0.86 | NPY4R (0.56) | BACE1BACE2PTPN1 | |
| SCHEMBL2519495 | 0.86 | ACE (0.56) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1018977-A4 | METHOD AND IMPLANTABLE ARTICLE FOR PROMOTING ENDOTHELIALIZATION | SURMODICS INC (US) | 2000-11-08 | — | — | EP | disclosed |
| EP-1018977-A1 | METHOD AND IMPLANTABLE ARTICLE FOR PROMOTING ENDOTHELIALIZATION | SurModics, Inc. (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1996037165-A1 | METHOD AND IMPLANTABLE ARTICLE FOR PROMOTING ENDOTHELIALIZATION | BSI CORPORATION (US) | 1996-11-28 | — | — | WO | disclosed |