Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.81 |
| ▸ | JAK2 | O60674 | 8/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793104 | 0.90 | TYK2 (1.00) | TYK2JAK2 | |
| SCHEMBL792586 | 0.87 | TYK2 (0.86) | TYK2JAK2 | |
| SCHEMBL793004 | 0.86 | TYK2 (0.77) | TYK2JAK2 | |
| SCHEMBL793802 | 0.86 | TYK2 (0.80) | TYK2JAK2 | |
| SCHEMBL792134 | 0.86 | TYK2 (0.80) | TYK2JAK2 | |
| SCHEMBL792938 | 0.85 | TYK2 (0.79) | TYK2JAK2 | |
| SCHEMBL792704 | 0.84 | TYK2 (0.70) | TYK2JAK2 | |
| SCHEMBL793404 | 0.84 | TYK2 (0.70) | TYK2JAK2 | |
| SCHEMBL11899895 | 0.83 | TYK2 (0.73) | TYK2JAK2 | |
| SCHEMBL792573 | 0.83 | TYK2 (1.00) | TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |