Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.80 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.80 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.80 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.80 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.80 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.80 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.80 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.80 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.80 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.80 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1064411 | 0.89 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL2360192 | 0.89 | F10 (0.72) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL2828860 | 0.88 | HDAC1 (0.74) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL2830015 | 0.88 | HDAC1 (0.74) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL211201 | 0.86 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL2499023 | 0.84 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL4577831 | 0.83 | HDAC2 (0.70) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL3111008 | 0.83 | HDAC1 (0.74) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL8401704 | 0.83 | HDAC1 (0.89) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL2413063 | 0.82 | HDAC1 (0.66) | HDAC1HDAC3HDAC2HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735319-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2017-05-03 | — | — | EP | disclosed |
| WO-2009033281-A1 | CANCER COMBINATION THERAPY WITH A SELECTIVE INHIBITOR OF HISTONE DEACETYLASE HDAC1, HDAC2 AND/OR HDAC3 AND A MICROTUBULE STABILIZER | METHYLGENE INC. (CA) | 2009-03-19 | — | — | WO | disclosed |
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |