Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LONP1 | P36776 | 13/20 | 0.70 |
| ▸ | PSMB5 | P28074 | 14/20 | 0.64 |
| ▸ | PSMB11 | A5LHX3 | 8/20 | 0.64 |
| ▸ | PSMA7 | O14818 | 8/20 | 0.64 |
| ▸ | PSMB1 | P20618 | 8/20 | 0.64 |
| ▸ | PSMA1 | P25786 | 8/20 | 0.64 |
| ▸ | PSMA2 | P25787 | 8/20 | 0.64 |
| ▸ | PSMA3 | P25788 | 8/20 | 0.64 |
| ▸ | PSMA4 | P25789 | 8/20 | 0.64 |
| ▸ | PSMB8 | P28062 | 8/20 | 0.64 |
| ▸ | PSMB9 | P28065 | 8/20 | 0.64 |
| ▸ | PSMA5 | P28066 | 8/20 | 0.64 |
| ▸ | PSMB4 | P28070 | 8/20 | 0.64 |
| ▸ | PSMB6 | P28072 | 8/20 | 0.64 |
| ▸ | PSMB10 | P40306 | 8/20 | 0.64 |
| ▸ | PSMB3 | P49720 | 8/20 | 0.64 |
| ▸ | PSMB2 | P49721 | 8/20 | 0.64 |
| ▸ | PSMA6 | P60900 | 8/20 | 0.64 |
| ▸ | PSMA8 | Q8TAA3 | 8/20 | 0.64 |
| ▸ | PSMB7 | Q99436 | 8/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423345 | 1.00 | LONP1 (0.70) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL464431 | 1.00 | LONP1 (0.70) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL20093526 | 1.00 | LONP1 (0.70) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL22546680 | 0.92 | LONP1 (0.58) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL20365811 | 0.83 | LONP1 (0.70) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL464440 | 0.83 | LONP1 (1.00) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| Bortezomib SCHEMBL8099424 | 0.78 | PSMB5 (1.00) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| Bortezomib SCHEMBL8035134 | 0.78 | PSMB5 (1.00) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| Bortezomib SCHEMBL192129 | 0.78 | PSMB5 (1.00) | LONP1PSMB5PSMB11PSMA7PSMB1 | |
| Bortezomib SCHEMBL29377226 | 0.78 | PSMB5 (1.00) | LONP1PSMB5PSMB11PSMA7PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212334-B1 | PROTEASOME INHIBITORS | MILLENNIUM PHARM INC (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2009051581-A1 | PROTEASOME INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-04-23 | — | — | WO | disclosed |