Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | IL6 | P05231 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 5/20 | 0.32 |
| ▸ | NOS1 | P29475 | 5/20 | 0.32 |
| ▸ | NOS3 | P29474 | 4/20 | 0.32 |
| ▸ | F2 | P00734 | 4/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14872317 | 0.77 | PIK3CD (0.33) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL6468950 | 0.76 | MEN1 (0.44) | MEN1KMT2AF2 | |
| SCHEMBL20019538 | 0.76 | MEN1 (0.41) | MEN1KMT2A | |
| SCHEMBL3984933 | 0.76 | CYP1A2 (0.42) | MEN1KMT2A | |
| SCHEMBL11960349 | 0.75 | PIK3CD (0.31) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL1725245 | 0.75 | — | — | |
| SCHEMBL5132531 | 0.74 | MEN1 (0.42) | MEN1KMT2AIL6TLR7NOS2 | |
| SCHEMBL24656203 | 0.72 | PIK3CD (0.47) | MEN1KMT2APIK3CDPIK3CAPIK3CB | |
| SCHEMBL6468946 | 0.72 | MEN1 (0.41) | MEN1KMT2AF2 | |
| SCHEMBL6470756 | 0.71 | MEN1 (0.40) | MEN1KMT2ANOS2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091584-A1 | THIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS TYK2 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-25 | — | — | WO | disclosed |
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |