SCHEMBL8079807

SCHEMBL8079807

CCc1c(NC(=O)C=O)c2c(OCC(=O)O)cccn2c1Cc1cccc(Cl)c1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PLA2G1B P04054 17/20 0.68
PLA2G2A P14555 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9082363 0.92 PLA2G1B (0.57) PLA2G1BPLA2G2A
SCHEMBL8026443 0.91 PLA2G1B (0.57) PLA2G1BPLA2G2A
SCHEMBL8025842 0.90 PLA2G1B (0.64) PLA2G1BPLA2G2A
SCHEMBL8507738 0.87 PLA2G1B (0.68) PLA2G1BPLA2G2A
SCHEMBL9081699 0.85 PLA2G1B (0.49) PLA2G1BPLA2G2A
SCHEMBL8026001 0.82 PLA2G1B (0.54) PLA2G1BPLA2G2A
SCHEMBL8022479 0.81 PLA2G1B (0.53) PLA2G1BPLA2G2A
SCHEMBL8322199 0.81 PLA2G1B (1.00) PLA2G1BPLA2G2A
SCHEMBL8071903 0.80 PLA2G1B (0.59) PLA2G1BPLA2G2A
SCHEMBL8084309 0.80 PLA2G1B (0.69) PLA2G1BPLA2G2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037630-A2 METHOD FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH APOPTOSIS USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS SHIONOGI & CO., LTD. (JP) 2000-09-27 EP claimed
WO-1999024026-A2 METHOD FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH APOPTOSIS USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS SHIONOGI & CO., LTD. (JP) 1999-05-20 WO claimed
WO-1996003383-A1 INDOLIZINE sPLA2 INHIBITORS ELI LILLY AND COMPANY (US) 1996-02-08 WO disclosed