Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.60 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.60 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080043 | 1.00 | SRD5A2 (0.60) | SRD5A2SRD5A1AR | |
| SCHEMBL9112301 | 0.89 | SRD5A1 (0.61) | SRD5A2SRD5A1AR | |
| SCHEMBL8073539 | 0.89 | SRD5A1 (0.61) | SRD5A2SRD5A1AR | |
| SCHEMBL8064120 | 0.88 | SRD5A1 (0.60) | SRD5A2SRD5A1AR | |
| SCHEMBL8064128 | 0.88 | SRD5A1 (0.60) | SRD5A2SRD5A1AR | |
| SCHEMBL27970660 | 0.87 | SRD5A2 (0.60) | SRD5A2SRD5A1AR | |
| SCHEMBL8726875 | 0.85 | SRD5A2 (0.58) | SRD5A2SRD5A1AR | |
| SCHEMBL8726881 | 0.85 | SRD5A2 (0.58) | SRD5A2SRD5A1AR | |
| SCHEMBL3957308 | 0.84 | SRD5A1 (0.59) | SRD5A2SRD5A1AR | |
| SCHEMBL4880617 | 0.84 | SRD5A1 (0.59) | SRD5A2SRD5A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641204-B1 | 17-ETHERS AND THIOETHERS OF 4-AZA-STEROIDS | MERCK & CO INC (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5693809-A | PREGNANES FOR TREATING ALOPECIA, ACNE AND SKIN DISORDER | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5536727-A | TREATMENT OF HYPERANDROGENIC DISEASES | MERCK & CO., INC. (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0641204-A4 | 17-ETHERS AND THIOETHERS OF 4-AZA-STEROIDS. | MERCK & CO INC (US) | 1995-08-23 | — | — | EP | disclosed |
| EP-0641204-A1 | 17-ETHERS AND THIOETHERS OF 4-AZA-STEROIDS | MERCK & CO. INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023039-A1 | SUBSTITUTED 4-AZA-5A-ANDROSTAN-ONES AS 5A-REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| WO-1993023040-A1 | 17-ETHERS AND THIOETHERS OF 4-AZA-STEROIDS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | disclosed |