Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.88 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | CRHBP | P24387 | 1/20 | 0.65 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11022539 | 1.00 | TDP1 (0.88) | TDP1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7571535 | 1.00 | TDP1 (0.88) | TDP1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7429207 | 0.98 | TDP1 (0.91) | TDP1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7429680 | 0.95 | TDP1 (0.81) | TDP1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7434380 | 0.94 | TDP1 (0.83) | TDP1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7426974 | 0.94 | TDP1 (1.00) | TDP1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL11565405 | 0.93 | TDP1 (0.76) | TDP1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7636957 | 0.93 | TDP1 (0.76) | TDP1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7644500 | 0.93 | TDP1 (0.76) | TDP1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7638526 | 0.91 | TDP1 (0.78) | TDP1L3MBTL1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048989-A | PARASITICIDES AND ANTIBROTOZOA AGENTS | WASHINGTON UNIVERSITY (US) | 2000-04-11 | — | — | US | disclosed |
| US-6025511-A | A MYRISTIC ACID SELECTED ANALOGS FOR INHIBITING THE BIOSYNTHESIS OF THE GLYCOSYL PHOSPHATIDYLINOSITOL (GPI) ANCHOR OF THE PARASITE | WASHINGTON UNIVERSITY (US) | 2000-02-15 | — | — | US | disclosed |
| US-6001869-A | CONTACTING THE PARASITE WITH 2-THIENYL-UNDECENOIC ACID/10-/ | WASHINGTON UNIVERSITY (US) | 1999-12-14 | — | — | US | disclosed |
| US-5998642-A | Thienyl-containing fatty acid glycosyl phosphatidylinosital analogues used for inhibiting parasitic activity | WASHINGTON UNIVERSITY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5760259-A | MYRISTIC ACID DERIVATIVES CAPABLE OF INHIBITING BIOSYNTHESIS OF PARASITE'S ANCHORING GROUP | WASHINGTON UNIVERSITY (US) | 1998-06-02 | — | — | US | disclosed |
| US-5747537-A | Method of inhibiting parasitic activity | WASHINGTON UNIVERSITY (US) | 1998-05-05 | — | — | US | disclosed |