Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.62 |
| ▸ | MTOR | P42345 | 3/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 17/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 17/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 17/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 17/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 17/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 17/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 17/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 17/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 17/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 17/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11986004 | 0.91 | PIK3CA (0.76) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL945810 | 0.90 | PIK3CA (0.66) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL8067046 | 0.88 | PIK3CA (0.62) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL8079833 | 0.88 | PIK3CA (0.80) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL7946722 | 0.87 | PIK3CA (0.56) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL12910339 | 0.86 | PIK3CA (0.68) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL12910340 | 0.85 | PIK3CA (0.64) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL14731750 | 0.82 | PIK3CA (0.74) | PIK3CAMTORHDAC3HDAC4HDAC1 | |
| SCHEMBL11980021 | 0.82 | PIK3CA (0.48) | PIK3CAMTORPIK3R1PIK3CDJAK2 | |
| SCHEMBL12910341 | 0.81 | PIK3CA (0.59) | PIK3CAMTORHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| WO-2009045174-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | PIK3CA, TPMT, MTOR | PIK3CA 1/4885MTOR 3/4885HDAC3 3655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.