Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083408 | 0.89 | EGFR (0.58) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8082240 | 0.86 | EGFR (0.71) | EGFRERBB2MAPK1HIF1AKDM4E | |
| SCHEMBL8871418 | 0.84 | EGFR (0.71) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8871347 | 0.83 | EGFR (0.62) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL2100551 | 0.77 | EGFR (0.82) | EGFRERBB2MAPK1HIF1AKDM4E | |
| SCHEMBL8872430 | 0.76 | EGFR (0.72) | EGFRERBB2MAPK1 | |
| SCHEMBL8075043 | 0.76 | EGFR (0.71) | EGFRERBB2MAPK1HIF1AKDM4E | |
| SCHEMBL8871490 | 0.75 | EGFR (0.72) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL9215676 | 0.75 | EGFR (0.74) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL2102382 | 0.75 | EGFR (0.82) | EGFRERBB2MAPK1HIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823901-B1 | QUINAZOLINE DERIVATIVE | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | claimed |
| EP-0823901-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1998-02-18 | — | — | EP | claimed |
| WO-1996033981-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | claimed |
| EP-0823901-B1 | QUINAZOLINE DERIVATIVE | ZENECA LTD (GB) | 2000-10-18 | — | — | EP | disclosed |
| US-5952333-A | INHIBITOR OF TYROSINE KINASE RECEPTOR FOR TREATING PROLIFERATIVE DISEASE SUCH AS CANCER | ZENECA LIMITED (GB) | 1999-09-14 | — | — | US | disclosed |
| EP-0823901-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996033981-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |