Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL28211900 | 0.97 | SMN1; SMN2 (0.39) | TP53SMN1; SMN2MAPTKDM4EALOX15 | |
| Trolamine SCHEMBL27786163 | 0.94 | SMN1; SMN2 (0.46) | TP53SMN1; SMN2MAPTKDM4EALOX15 | |
| Trolamine SCHEMBL28031872 | 0.94 | TP53 (0.41) | TP53SMN1; SMN2MAPTKDM4EALOX15 | |
| Trolamine SCHEMBL8447470 | 0.94 | TP53 (0.41) | TP53SMN1; SMN2MAPTKDM4EALOX15 | |
| Trolamine SCHEMBL28225633 | 0.89 | SMN1; SMN2 (0.43) | TP53SMN1; SMN2MAPTKDM4EALOX15 | |
| Trolamine SCHEMBL27804709 | 0.89 | SMN1; SMN2 (0.43) | TP53SMN1; SMN2MAPTKDM4EALOX15 | |
| Trolamine SCHEMBL17673124 | 0.86 | MEN1 (0.42) | TP53SMN1; SMN2MAPTKDM4EALOX15 | |
| Sulfuric Acid SCHEMBL28484916 | 0.85 | SMN1; SMN2 (0.40) | TP53SMN1; SMN2MAPTKDM4EALOX15 | |
| Trolamine SCHEMBL27984192 | 0.83 | SMN1; SMN2 (0.43) | TP53SMN1; SMN2MAPTKDM4EALOX15 | |
| Trolamine SCHEMBL5033125 | 0.83 | CYP1A2 (0.41) | TP53SMN1; SMN2MAPTKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114306240-A | Gemcitabine or liposome of salt thereof, preparation method and application thereof | 四川科伦药物研究院有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-114306240-A | Gemcitabine or liposome of salt thereof, preparation method and application thereof | 四川科伦药物研究院有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-107892852-A | A kind of furniture paint | 徐州隆邦家具有限公司 | 2018-04-10 | — | — | CN | disclosed |
| EP-1045936-A1 | AQUEOUS COMPOSITIONS COMPRISING COMPLEXING AGENTS AND USES THEROF | THE PROCTER & GAMBLE COMPANY (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999039045-A1 | AQUEOUS COMPOSITIONS COMPRISING COMPLEXING AGENTS AND USES THEROF | THE PROCTER & GAMBLE COMPANY (US) | 1999-08-05 | — | — | WO | disclosed |
| US-4030907-A | COMPLEX OF COPPER SALT WITH AN ALKANOLAMINE AND AMMONIUM COMPOUND | THOMPSON-HAYWARD CHEMICAL CO. (US) | 1977-06-21 | — | — | US | disclosed |