Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 18/20 | 0.67 |
| ▸ | HCRTR1 | O43613 | 16/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12024836 | 0.93 | HCRTR2 (0.77) | HCRTR2HCRTR1HTR1AOPRM1DRD3 | |
| SCHEMBL3487028 | 0.80 | HCRTR2 (0.60) | HCRTR2HCRTR1HTR1AOPRM1DRD3 | |
| SCHEMBL3622483 | 0.80 | HCRTR2 (1.00) | HCRTR2HCRTR1HTR1AOPRM1DRD3 | |
| SCHEMBL3023755 | 0.78 | HCRTR2 (0.62) | HCRTR2HCRTR1HTR1AOPRM1DRD3 | |
| SCHEMBL8086304 | 0.76 | HCRTR2 (0.72) | HCRTR2HCRTR1HTR1AOPRM1DRD3 | |
| SCHEMBL8081046 | 0.75 | HCRTR2 (0.73) | HCRTR2HCRTR1HTR1AOPRM1DRD3 | |
| SCHEMBL13498698 | 0.75 | HCRTR2 (0.69) | HCRTR2HCRTR1HTR1AOPRM1DRD3 | |
| SCHEMBL13499116 | 0.75 | HCRTR2 (0.56) | HCRTR2HCRTR1HTR1AOPRM1DRD3 | |
| SCHEMBL3622904 | 0.75 | HCRTR1 (1.00) | HCRTR2HCRTR1HTR1AOPRM1DRD3 | |
| SCHEMBL14548868 | 0.74 | HCRTR2 (0.56) | HCRTR2HCRTR1HTR1AOPRM1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020642-A1 | PYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2009-02-12 | — | — | WO | disclosed |