Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.50 |
| ▸ | MTOR | P42345 | 7/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083676 | 0.92 | PIK3CA (0.46) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8092989 | 0.92 | PIK3CA (0.46) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8083867 | 0.91 | PIK3CA (0.52) | PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL8089003 | 0.90 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8092066 | 0.89 | PIK3CA (0.44) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8091068 | 0.88 | PIK3CD (0.42) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8092236 | 0.88 | PIK3CA (0.44) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8092043 | 0.88 | MTOR (0.49) | PIK3CAMTORPIK3CDPIK3CGATR | |
| SCHEMBL8083160 | 0.87 | PIK3CD (0.43) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8083631 | 0.86 | PIK3CD (0.41) | PIK3CAMTORPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |