Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 12/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092629 | 0.95 | MTOR (0.48) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8093447 | 0.93 | MTOR (0.43) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8091084 | 0.90 | PIK3CD (0.47) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8092188 | 0.90 | PIK3CA (0.45) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8090759 | 0.90 | MTOR (0.41) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8092043 | 0.90 | MTOR (0.49) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL8089003 | 0.88 | PIK3CA (0.56) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8089909 | 0.87 | MTOR (0.45) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8096190 | 0.86 | PIK3CA (0.50) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL8090907 | 0.85 | MTOR (0.46) | MTORPIK3CAPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |