SCHEMBL8084827

SCHEMBL8084827

Cc1nn(-c2ccccc2)c(S)c1C(=O)O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.65
CYP2C9 P11712 1/20 0.65
CYP2C19 P33261 1/20 0.65
POLB P06746 4/20 0.60
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
HPGD P15428 4/20 0.52
MAPT P10636 4/20 0.52
RAB9A P51151 4/20 0.52
TDP1 Q9NUW8 2/20 0.52
NPSR1 Q6W5P4 1/20 0.52
PDE4D Q08499 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
NPC1 O15118 3/20 0.49
KDM4E B2RXH2 2/20 0.48
ALDH1A1 P00352 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
APEX1 P27695 1/20 0.47
ABCB1 P08183 1/20 0.47
LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11110984 0.89 CYP1A2 (0.55) CYP1A2CYP2C9CYP2C19POLBKMT2A
SCHEMBL2938583 0.83 MEN1 (0.69) CYP1A2CYP2C9CYP2C19POLBMEN1
SCHEMBL27848785 0.82 PDE4D (0.75) CYP2C9CYP2C19MEN1KMT2AHPGD
SCHEMBL8090996 0.81 CYP1A2 (0.67) CYP1A2CYP2C9CYP2C19POLBMEN1
SCHEMBL5067031 0.80 HPGD (0.73) CYP1A2CYP2C9CYP2C19POLBMEN1
SCHEMBL6681735 0.80 HPGD (0.69) CYP1A2CYP2C9CYP2C19POLBMEN1
SCHEMBL14132434 0.79 CYP2C9 (1.00) CYP1A2CYP2C9CYP2C19POLBMEN1
SCHEMBL11476853 0.78 CYP1A2 (0.61) CYP1A2CYP2C9CYP2C19POLBMEN1
SCHEMBL10513918 0.77 KDM4E (0.45) CYP1A2CYP2C9CYP2C19POLBMEN1
SCHEMBL20427928 0.76 CYP1A2 (0.60) CYP1A2CYP2C9CYP2C19POLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6133270-A Isothiazolones and pharmaceutical formulations WARNER-LAMBERT COMPANY (US) 2000-10-17 US disclosed
US-6001863-A USEFUL AS ANTIVIRAL, ANTIINFLAMMATORY AND ANTIATHEROSCLEROSIS AGENT; ADMINISTERING TO THE PATIENT IN NEED OF ZINC EJECTION FROM NUCLEOCAPSID PROTEIN WARNER-LAMBERT COMPANY (US) 1999-12-14 US disclosed
US-5889034-A ANTIINFLAMMATORY AGENT; ANTIATHEROSCLEROSIS AGENT; VIRICIDES WARNER-LAMBERT COMPANY (US) 1999-03-30 US disclosed
US-5733921-A ANTIRETROVIRAL AGENTS; ANTIINFLAMMATORY AGENTS; ANTIATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1998-03-31 US disclosed
EP-0828488-A1 ISOTHIAZOLONES WARNER-LAMBERT COMPANY (US) 1998-03-18 EP disclosed
US-5668162-A Isothiazolones lower plasma levels of lipoprotein(a) WARNER-LAMBERT COMPANY 1997-09-16 US disclosed
US-5620997-A VIRICIDES, ANTIINFLAMMATORY AGENTS, ANTIATHEROSCLEROTIC AGENT WARNER-LAMBERT COMPANY (US) 1997-04-15 US disclosed
WO-1996038144-A1 ISOTHIAZOLONES WARNER-LAMBERT COMPANY (US) 1996-12-05 WO disclosed