Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5973850 | 0.80 | POLB (0.37) | HRH4NR1I3KDM4EMEN1KMT2A | |
| SCHEMBL8086041 | 0.75 | TDP1 (0.36) | — | |
| SCHEMBL5973965 | 0.75 | HRH4 (0.33) | HRH4NR1I3KDM4EMEN1KMT2A | |
| SCHEMBL7676206 | 0.74 | HRH4 (0.38) | HRH4NR1I3GSK3BPTGES | |
| SCHEMBL27513154 | 0.72 | HRH4 (0.32) | HRH4NR1I3CRHR1PTGES | |
| SCHEMBL27529467 | 0.70 | NQO2 (0.43) | HRH4NR1I3KDM4EMEN1KMT2A | |
| SCHEMBL8086933 | 0.70 | SIRT2 (0.35) | HRH4 | |
| SCHEMBL8086008 | 0.70 | TLR8 (0.34) | HRH4KDM4EKMT2ACRHR1 | |
| SCHEMBL6306591 | 0.69 | HRH4 (0.60) | HRH4NR1I3KDM4EMEN1KMT2A | |
| SCHEMBL14126693 | 0.69 | RXFP1 (0.41) | KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1137886-C | 2,3-dioxo-1,2,3,4-tetrahydro-quinoyxalinyl derivatives | ��˹��ŵ�� | 2004-02-11 | — | — | CN | disclosed |
| US-6080743-A | AS CHEMICAL INTERMEIDATES FOR PREPARING DRUGS | NOVARTIS AG (CH) | 2000-06-27 | — | — | US | disclosed |
| CN-1194649-A | Quinoxaline-and quinoxalinylalkane-phosphonic acids | NOVARTIS AG (CH) | 1998-09-30 | — | — | CN | disclosed |
| CN-1193968-A | 2,3-dioxo-1,2,3,4-tetrahydro-quinoyxalinyl derivatives | NOVARTIS AG (CH) | 1998-09-23 | — | — | CN | disclosed |
| EP-0853617-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | Novartis AG (CH) | 1998-07-22 | — | — | EP | disclosed |
| EP-0837864-A1 | NOVEL QUINOXALINE- AND QUINOXALINYLALKANE-PHOSPHONIC ACIDS | Novartis AG (CH) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997008155-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |
| WO-1997003079-A1 | NOVEL QUINOXALINE- AND QUINOXALINYLALKANE-PHOSPHONIC ACIDS | NOVARTIS AG (CH) | 1997-01-30 | — | — | WO | disclosed |