Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.64 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.64 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.64 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.64 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.64 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.47 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.47 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.47 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.47 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.47 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085710 | 0.86 | GRIN2D (0.72) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8078954 | 0.84 | GRIN1 (0.70) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8086083 | 0.84 | GRIN1 (0.66) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8087147 | 0.83 | GRIN2D (0.59) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8086905 | 0.81 | GRIN2D (0.62) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8563630 | 0.79 | GRIN1 (0.63) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8087304 | 0.79 | GRIN1 (0.63) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8078843 | 0.79 | GRIN1 (0.71) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| Bromide SCHEMBL8092051 | 0.78 | GRIN1 (0.61) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8092107 | 0.78 | GRIN2D (0.62) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1193968-A | 2,3-dioxo-1,2,3,4-tetrahydro-quinoyxalinyl derivatives | NOVARTIS AG (CH) | 1998-09-23 | — | — | CN | claimed |
| US-6080743-A | AS CHEMICAL INTERMEIDATES FOR PREPARING DRUGS | NOVARTIS AG (CH) | 2000-06-27 | — | — | US | disclosed |
| CN-1197452-A | Azetidinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | CN | disclosed |
| EP-0853617-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | Novartis AG (CH) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997008155-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |