Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.42 |
| ▸ | GLI1 | P08151 | 2/20 | 0.40 |
| ▸ | GLI2 | P10070 | 2/20 | 0.40 |
| ▸ | MLYCD | O95822 | 5/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.37 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.37 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.37 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3649918 | 0.90 | TACR1 (0.44) | TACR1MLYCDSLC6A9PDPK1MEN1 | |
| SCHEMBL3645573 | 0.90 | PTGIR (0.43) | TACR1MLYCDSLC6A9PDPK1MEN1 | |
| SCHEMBL3645993 | 0.90 | TACR1 (0.44) | TACR1MLYCDSLC6A9PDPK1MEN1 | |
| SCHEMBL3645996 | 0.90 | TACR1 (0.44) | TACR1MLYCDSLC6A9PDPK1MEN1 | |
| SCHEMBL8082608 | 0.88 | TACR1 (0.43) | TACR1GLI1GLI2SLC6A9PDPK1 | |
| SCHEMBL4155415 | 0.87 | SERPINE1 (0.44) | TACR1SLC6A9 | |
| SCHEMBL3642140 | 0.87 | CHRM5 (0.45) | TACR1SLC6A9MEN1KMT2A | |
| SCHEMBL3644592 | 0.86 | PPARG (0.45) | TACR1SLC6A9 | |
| SCHEMBL3649784 | 0.86 | PPARG (0.45) | TACR1SLC6A9 | |
| SCHEMBL3644589 | 0.86 | PPARG (0.45) | TACR1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016087-A1 | MONOAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |