Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851989 | 0.72 | KDM4E (0.38) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL17137666 | 0.72 | KDM4E (0.38) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL20658012 | 0.70 | SMN1; SMN2 (0.36) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL24112225 | 0.70 | CRBN (0.31) | ALDH1A1CRBN | |
| SCHEMBL24112723 | 0.70 | CRBN (0.31) | ALDH1A1CRBN | |
| SCHEMBL19584730 | 0.69 | KDM4E (0.36) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL11757969 | 0.69 | KDM4E (0.47) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL24112818 | 0.67 | — | — | |
| SCHEMBL8089735 | 0.67 | CYP1A2 (0.35) | KDM4EPOLBMAPTALDH1A1KMT2A | |
| SCHEMBL24112224 | 0.66 | CRBN (0.31) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009013535-A1 | 2-AZABICYCLO(2.2.2)OCTANE DERIVATIVES AS MODULATORS OF THE GLYCINE TRANSPORTER I RECEPTOR | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | WO | disclosed |